Buscon Injection 1 ml

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Buscon
Hyoscine Butylbromide
Composition: Each 1 ml ampoule contains Hyoscine Butylbromide BP 20 mg. tablet: Each tablet contains 10 mg
Hyoscine Butylbromide BP.
Pharmacological action: Hyoscine butylbromide is a quaternary ammonium antimuscarinic agent. Hyoscine
butylbromide does not readily pass the blood-brain barrier. It is a competitive antagonist of the actions of
acetylcholine and other muscarinic agonists.
Indications: Hyoscine butylbromide is used in the treatment of conditions associated with gastrointestinal spasm.
Contraindications: Hypersensitivity to Hyoscine butylbromide. Patients with prostatic enlargement, paralytic ileus or
pyloric stenosis. It should not be given to patients with myasthenia gravis, unless it is to reduce the adverse muscarinic effects
of an anticholinesterase agent. It should be given with caution to pregnant and lactating mothers as safety has not yet been
established. It has been stated to cross the placenta.
Dosage and administration: The usual dose is 20 mg intramuscular or intravenous, repeated after 30 minutes, if necessary.
Oral: smooth muscle spasm, 20 mg 4 times daily; Child (6-12 years): 10 mg 3 times daily. Irritable bowel syndrome, 10
mg 3 times daily, increased if required up to 20 mg 4 times daily.
Side-effects and special precautions: Dryness of the mouth, with difficulty in swallowing, thirst, dilatation of the pupils
with loss of accommodation and photophobia, increased intra-ocular pressure, flushing and dryness of the skin,
bradycardia followed by tachycardia, with palpitations and arrhythmias, urinary urgency with the inability to do so, as
well as reduction in the tone and motility of the gastrointestinal tract, leading to constipation. Occasionally vomiting,
giddiness and staggering may occur. Retrosternal pain may occur due to increased gastric reflux.Patients who
experience drowsiness should not drive or operate machinery. Alcohol should be avoided. It has been stated that in elderly
patients and patients with inpaired metabolic, liver or Kidney function, adverse central nervous system effects such as
disorientation, delirium or somnolence have been more likely to occur. It should be used with caution in conditions
characterized by tachycardia such as thyrotoxicosis, cardiac insufficiency or failure, and in cardiac surgery where it may
further accelerate the heart-rate. Care is required in patients with acute myocardial infarction as ischemia and
infarction may be worsened. It should be given with care to patients with hypertension.Hyoscine should be used with care in
patients receiving other central depressants concomitantly, as central nervous system depression may be enhanced.
The effects of antimuscarinic agents may be enhanced by drugs with antimuscarinic properties, such as amantadine,
some antihistamines, butyrophenones and phenothiazines, and antidepressants.
Symptoms of overdosage: Toxic doses cause tachycardia, rapid respiration, hyperpyrexia, restlessness, confusion,
excitement, impotence and hallucinations passing into delirium. A rash may appear on face and upper trunk, In severe
intoxication, depression of the central nervous system may occur with circulatory failure and respiratory failure.
Quaternary ammonium anticholinergic agents usually have some ganglion blocking action, so that high doses may cause
postural hypertension and impotence in toxic doses, nondepolarising neuromuscular block may be produced.
Supportive and symptomatic therapy should be given as required.
Storage condition: Store in a cool & dry place.
Presentation: Each box contains 5’s x 2 blistered 1 ml ampoule. Each box contains 10×10’s tablets in blister strip.

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