DELANZO 60mg, 30’s pack

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Dexlansoprazole is indicated for-

  • Healing of all grades of Erosive Esophagitis (EE) for up to 8 weeks.
  • Maintain healing of Erosive Esophagitis and relief of heartburn for up to 6 month.
  • Treatment of heartburn associated with symptomatic Non-Erosive Gastroesophageal Reflux Disease (GERD) for 4 weeks.

Therapeutic Class

Proton Pump Inhibitor


Dexlansoprazole delayed-release capsule is a Proton Pump Inhibitor (PPI), that inhibits gastric acid secretion. It is the R-enantiomer of lansoprazole (A racemic mixture of the R- and S-enantiomers). This is supplied as a Dual Delayed Release (DDR) formulation in a capsule for oral administration. Dexlansoprazole capsule contains a mixture of two types of enteric coated granules with different pH-dependent dissolution profiles.

Dexlansoprazole is a PPI that suppresses gastric acid secretion by specific inhibition of the (H+/K+)-ATPase in the gastric parietal cell. By acting specifically on the proton pump, Dexlansoprazole blocks the final step of acid production.


  • Maintenance of Healed Erosive Esophagitis and relief of heartburn: 30 mg once daily.
  • Symptomatic Non-Erosive GERD: 30 mg once daily for 4 weeks.
  • Healing of Erosive Esophagitis: 60 mg once daily for up to 8 weeks.


Dexlansoprazole can be taken without regard to food or the timing of food. It should be swallowed whole. If a capsule is missed at its usual time, it should be taken as soon as possible. But if it is too close to the time of the next dose, only the prescribed dose should be taken at the appointed time. A double dose should not be taken.


Lansoprazole appears to be a selective inhibitor of the cytochrome P-450 monooxygenase system; there may be an effect on hepatic clearance, but there have been no reports to date of clinically relevant interactions. There is some uncertainty over the effect of Lansoprazole on the oral combined contraceptive pill. Further assessment is currently underway. Physiological changes similar to those found with Omeprazole are likely to take place because of the reduction in gastric acid, which is likely to influence the bacterial colonization of the stomach and duodenum and also vitamin B12 absorption.


Dexlansoprazole is contraindicated in patients with known hypersensitivity to any component of the formulation.

Side Effects

Common side effects are Diarrhea, abdominal pain, nausea, upper respiratory tract Infection, vomiting & flatulence.

Pregnancy & Lactation

There are no adequate or well-controlled studies in pregnant women with Dexlansoprazole. Exposure in clinical trials was very limited. Dexlansoprazole should not be administered to pregnant women unless the expected benefits outweigh the potential risks. It is not known whether dexlansoprazole is excreted in human milk. However, Dexlansoprazole and its metabolites are excreted in the milk of rats. As many drugs are excreted in human milk, Dexlansoprazole should not be given to nursing mothers unless its use is considered

Precautions & Warnings

Gastric malignancy, Clostridium difficile associated diarrhea, bone fracture, hypomagnesemia, concomitant use of Dexlansoprazole with Methotrexate.

Use in Special Populations

Geriatrics: No dosage adjustment is necessary for elderly patients.

Pediatrics: Safety and effectiveness of Dexlansoprazole in patients below 12 years age have not been established yet.

Renal Impairment: No dosage adjustment is necessary for patients with renal impairment.

Hepatic Impairment: No adjustment of Dexlansoprazole is necessary for patients with mild hepatic impairment. A maximum daily dose of 30 mg for patients with moderate hepatic impairment may be considered.

Overdose Effects

There have been no reports of significant overdose of Dexlansoprazole. Multiple doses of Dexlansoprazole 120 mg and a single dose of Dexlansoprazole 300 mg did not result in any severe adverse events.

Storage Conditions

Store at temperature not exceeding 30ºC in a dry place. Protect from light & moisture.
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