Tritin Tablet Trimebutine Maleate 100 mg

৳ 150

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Indications

Treatment and relief of symptoms associated with irritable bowel syndrome (spastic colon). Postoperative paralytic ileus in order to accelerate the resumption of the intestinal transit following abdominal surgery.

Therapeutic Class

Anticholinergics

Pharmacology

Trimebutine maleate is a noncompetitive spasmolytic agent. It possesses moderate opiate receptor affinity and has marked anti-serotonin activity especially on ‘mu’ receptors. It induces regulation of spontaneous activity and increases synchronization between electrophysiological spikes and contractions in isolated guinea pig strips of colon and ileum. However, it does not alter normal motility, but regulates abnormal intestinal activity.

Dosage & Administration

For adults: 100 mg to 200 mg, 3 times per day before meals.

Interaction

Trimebutine maleate increases the duration of d-tubocurarine-induced curarization. No other druginteractions have been observed during clinical trial or otherwise reported.

Contraindications

Patients with known hypersensitivity to trimebutine maleate or any excipient.

Side Effects

Trimebutine maleate is generally well tolerated. The infrequently reported adverse effects are as follows: dry mouth, foul taste, diarrhea, dyspepsia, epigastric pain, nausea, constipation, drowsiness, fatigue, dizziness, hot/cold sensations, headache etc.

Pregnancy & Lactation

Although teratological studies have not shown any drug related adverse effects on the course and outcome of pregnancy, the use of trimebutine maleate in pregnant women is not recommended.

It is not known if trimebutine maleate passes into breast milk. This medication should be used while breast feeding only if the potential benefits outweigh risks to the nursing infants.

Precautions & Warnings

Elderly, pregnancy and lactation

Overdose Effects

No evidence of overdosage have been reported to date. However, if overdosage should occur following oral administration, gastric lavage is recommended. Treatment should be made according to the symptoms observed.

Storage Conditions

Store in a cool and dry place, protected from light and moisture. Keep out of the reach of children.
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Tritin Tablet Trimebutine Maleate 100 mg

৳ 150

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